The focus of my summerplacement is on protein-ligand binding of the enzyme InhA using the novel method of 2D-Infrared Spectroscopy.
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| Crystal structure of wild-type InhA: NADH complex PDB: 3OEW |
InhA is a long-chain enoyl-acyl carrier protein reductase involved in the mycolic acid biosynthesis in Mycobacterium tuberculosis.
The later being the causative agent of TB which had an estimated 8.8 million cases globally reported in 2010 (source: WHO, 2011).
InhA has been identified as the main drug target of Isoniazid (INH) and Ethionamide (ETH) which have been used in the treatment of TB since the 1950s.
Like most other pathogenic organisms, there has been an increasing number of multi-drug resistant cases recently.
Therefore, it is of interest to elucidate the mechanism of how the resistance is confered.
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